DRUGS FOR OVERACTIVE BLADDER

All of these drugs are only modestly more effective than placebo for this indication.

( Enablex) and solifenacin, ( VESIcare)
like oxybutynin, tolterodine and trospium, are
muscuranic receptor antagonists.
although in animal studies solifenacin had an increased affinity to bladder Smooth muscle cells and less to the salivary gland cells in clinical practice. This might mean less dry mouth
and darifenacin has an increased affinity to M3, receptor than to the M1 receptor, so theoretically it has less CNS effects.
but on the whole cost-effectiveness Ditropan is as good as any other medication.


DRUGS FOR OVERACTIVE BLADDER
Darifenacin hydrobromide —
Enablex(Novartis) 7.5-15 mg PD once/d2 100$(7.5-, 15-mg ER tabs)
Oxybutynin chloride —
average generic price 5 mg PC bid or tid 25$(5-mg IR tabs; syrup)
Ditropan 75$
Ditropan XL 5-30 mg PC once/d 100 $(5-, 10-, 15-mg ER tabs)
Oxytrol I patch 2x/wk 90$(39 cm2 transdermal patch) (39 mgld)
Solifenacin succinate — VESicare 5 mg PC once/d4 100 $(5-, 10-mg tabs)
Tolterodine tartrate —
Detrol 1-2mg P0 bid5 100 $(1-. 2-mg IR tabs)
Detrol LA 2-4 mg P0 once/d5 100 $(2-. 4-mg ER caps)
Trospium chloride —
Sanctura (20 mg PC bid 90 $ Odyssey) (20-mg tabs)